This is a topic we've held off writing about until we could do it carefully. Pregnancy and breastfeeding change the safety calculus on almost everything, including products we sell — and the honest answer for several of them is "talk to your doctor first," not a confident green light. Here's what the actual guidance says, product by product.
Caffeine: the numbers that matter
A fact sheet from MotherToBaby, an NIH-affiliated service that reviews medication and supplement safety in pregnancy and breastfeeding, gives specific figures: most experts, drawing on ACOG guidance among other sources, recommend pregnant women limit caffeine intake to 200mg or less per day. Research shows increased concern — including miscarriage risk — at moderate-to-high intake levels above that.1 For breastfeeding, the same fact sheet gives a higher ceiling — 300mg or less per day — since only small amounts of caffeine pass into breast milk, though newborns clear caffeine much more slowly than adults, so timing after feeds matters more than it would otherwise.
200mg or less per day in pregnancy, 300mg or less while breastfeeding — and that's a total across everything you drink and take that day, not a per-product allowance.
Where this gets specific to Cognitive Support
We've written honestly before about the fact that Cognitive Support currently lists caffeine as an ingredient without a disclosed per-capsule milligram amount — that's a real labeling gap we're actively closing, not a number we're hiding.2 Until that number is on the label, we cannot responsibly tell a pregnant or breastfeeding customer how much of their daily 200mg or 300mg caffeine budget one dose uses up. Our honest guidance: don't take Cognitive Support during pregnancy or while breastfeeding until the caffeine dose is disclosed on the label, or unless your doctor has reviewed the full ingredient list and specifically cleared it.
Sleep Support and Sleep Formula: the melatonin question
Both of these products contain melatonin. A 2021 scoping review of human studies on melatonin use during pregnancy and lactation found the existing human data is limited — not evidence of harm, but not enough high-quality human safety data to give a confident blanket recommendation either.3 Melatonin is a hormone, and it does cross into breast milk and the placenta in measurable amounts. Given the limited human data, this is squarely a "discuss with your doctor before use" product during pregnancy or breastfeeding, not a self-directed decision either way.
Creatine Monohydrate: promising, but human safety data is still thin
Creatine Monohydrate has been discontinued from the Proco range — we're keeping this section because the underlying research question is still useful information.
Creatine is one of the most well-studied supplements in the general population, but that evidence doesn't automatically transfer to pregnancy. Most of the current safety research specific to pregnancy is still preclinical — a 2025 study modeling maternal creatine supplementation used a guinea pig model of full-term pregnancy, not human trial data.4 There's genuine scientific interest in creatine's potential role in supporting fetal development under stress conditions, but "interesting research direction" and "established safe for routine use in pregnancy" are different things. Talk to your doctor before continuing or starting creatine during pregnancy.
Omega-3 and Magnesium Glycinate: the more reassuring picture
These two have a comparatively better-established safety profile in pregnancy and breastfeeding — omega-3 (EPA/DHA) is commonly recommended during pregnancy for fetal brain and eye development, and magnesium is a standard part of prenatal nutrition guidance. That said, "generally well-supported by the evidence" is still not the same as "cleared without discussion" — confirm dosing with your doctor or OB, particularly around total intake from prenatal vitamins plus any additional supplement, so you're not unintentionally doubling up.
The one rule that covers everything on this page
None of this article is a substitute for a conversation with your own doctor, OB-GYN, or midwife, who knows your specific health history. Bring your supplement list — all of it, not just the ones you think might matter — to that conversation. That's true for Proco products and for anything else on your shelf.
References
- "Caffeine." MotherToBaby Fact Sheets, NCBI Bookshelf. ncbi.nlm.nih.gov
- "How Much Caffeine Is Actually in Cognitive Support?" Proco. procohq.com
- "Melatonin use during pregnancy and lactation: A scoping review of human studies." PubMed, 2021. pubmed.ncbi.nlm.nih.gov
- "Safety of maternal creatine supplementation: evidence from a guinea pig model of full-term pregnancy." Journal of the International Society of Sports Nutrition, 2025. tandfonline.com
This article is for informational purposes only and has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease, and it is not a substitute for medical advice. Always speak with your doctor, OB-GYN, or midwife before starting, continuing, or stopping any supplement during pregnancy or while breastfeeding — bring your full supplement list to that conversation.
Related reading: Does Cognitive Support Contain Caffeine? and Omega-3 and Postpartum Depression: What the Research Actually Shows
Full ingredient lists for every Proco product are always on the label — review them with your doctor at procohq.com.