Plain-language explainers on ADHD, autism, sleep, memory and more. Each one sets out what the evidence says and where it stops.
General information only, not medical advice. We are not a clinical service yet.
NAC's evidence is real but conditional: strong in clinical psychiatric contexts, and dependent on your baseline glutathione for the antioxidant claim.
Creatine raises serum creatinine, the same marker doctors use to estimate kidney function. Here is what the RCT data says about actual kidney harm.
"Third-party tested" is on every label and means almost nothing on its own. Here is what a real COA verifies.
The dose and timing most people use for melatonin are not what the trial data supports, and the safety data has real gaps.
10 minutes, 30 minutes, or a full cycle? We compare the pooled nap evidence against a controlled dose-ranging trial.
Alcohol helps you fall asleep faster, then fragments the rest of your night. Here is what the polysomnography data actually shows.
Curcumin's absorption problem is real. The famous fix — adding piperine for a claimed 2000% boost — traces to a flawed 1998 study that four independent groups have since failed to replicate.
"Omega-3 is good for your heart" sounds settled. A 2020 Cochrane review and a 2021 JAHA meta-analysis looked at overlapping evidence and reached genuinely different conclusions — here's both, honestly.
We sell supplements with real cognitive evidence behind them. In the interest of the same honesty we apply everywhere else, here's how that evidence actually compares to exercise — the single highest-evidence brain-health intervention there is.
"No caffeine after 2pm" is a blanket rule standing in for something more specific. A randomized crossover trial tested dose and timing together — and dose turned out to matter far more than the clock.
Rhodiola rosea has real evidence for exercise performance — and a rigorous trial using the correctly standardized extract that found it made fatigue worse. Here's why that inconsistency keeps it out of our range.
Most people reach for a sleep supplement before trying the interventions with far stronger evidence behind them. Here's what the actual evidence hierarchy looks like, ranked by effect size.
Does creatine work better before or after your workout? A widely cited small study says yes. A larger, more recent trial says timing doesn't matter at all.
Magnesium glycinate is often sold as "the best absorbed form" — but the head-to-head trial evidence actually points somewhere else. Here's why we still chose it, and the honest reason it isn't about absorption.
Ashwagandha's stress and cortisol evidence is strong — but only for specific standardized extracts like KSM-66. Here's why Proco's own ashwagandha stays in draft until sourcing matches the trials.
Bacopa monnieri's memory benefits are backed by real RCTs — but only after 6 to 12 weeks of consistent use. Here's the evidence, and why the timeline matters more than most marketing admits.
5-HTP has real clinical trial evidence for mood — and a serious, well-documented interaction risk with common antidepressants. Here's why that combination keeps it off the Proco shelf.
GABA is the brain's main calming neurotransmitter, but the evidence that oral GABA supplements actually reach the brain is thin and inconsistent. Here's why Proco doesn't sell one.
The brain-health aisle runs on proprietary blends and unproven trend ingredients. Here's exactly what our evidence standard requires, and a transparent list of what does and doesn't clear it.
L-theanine is one of the few "calm focus" ingredients with genuinely strong human trial evidence behind it. It's also not in our range — here's the honest reason why.
Roughly a third of US adults don't get the sleep they need. Here's what the research actually supports for improving it — and an honest note on why melatonin, despite real evidence behind it, isn't in our range yet.
Magnesium is marketed everywhere as a "calm" mineral. Here's what a real randomized controlled trial found about magnesium, stress, and the extra role vitamin B6 plays — and where the evidence is still thin.
DHA is a structural building block of the brain — but the dose-response research on omega-3 and cognition is more complicated than "more is better." Here's what a 58-trial meta-analysis actually found.
Creatine's reputation is built on muscle. A growing body of trials is now testing it on the brain — here's an honest read of what that evidence actually shows, including where regulators drew the line.
A step-by-step guide to reading a Supplement Facts panel properly — what a proprietary blend is hiding, how to check if a dose matches the research, and the red flags worth knowing.