Healthspan and lifespan are different metrics. Below: what the published research describes about the markers, mechanisms, and interventions linked to longer, healthier life.
A practical guide to the main ways to estimate biological age — epigenetic clocks, blood-biomarker scores, grip strength, VO2 max and telomere tests — and how reliable each is.
11 min read · 2026-06-04 SupplementsAstaxanthin is a marine carotenoid sold for longevity, skin and eyes. We review what human trials measure, what is preclinical, and where the evidence stops.
10 min read · 2026-06-04 AI and longevityA measured look at where AI genuinely contributes to ageing research, what has reached clinical stages, and why no AI has yet been shown to extend human healthspan.
12 min read · 2026-06-04 BiomarkersA measured, evidence-based look at which longevity biomarkers have strong data behind them, what targets research supports, and where consumer panels overreach.
12 min read · 2026-06-04 LongevityLongevity research distinguishes lifespan (total years lived) from healthspan (years lived in good health). This page describes the definitions, measurement, and current state of the field.
10 min read · 2026-06-01 Longevity biologyResearch has identified twelve specific cellular and molecular processes that together produce aging. This page describes the López-Otín hallmarks framework and what each contributes.
11 min read · 2026-06-01 Longevity measurementEpigenetic clocks use DNA methylation patterns to estimate chronological age, biological age, and rate of aging. This page describes the three generations of clocks and what each actually predicts.
11 min read · 2026-06-01 Longevity researchCaloric restriction has been studied for nearly a century. It extends healthy lifespan in multiple species. This page describes what the research has measured — from McCay 1935 to CALERIE 2023 — and the real risks.
12 min read · 2026-06-01 Biological ageWhat the published research describes about biological age tests — epigenetic clocks, telomere length, and proteomic clocks — how they work, what they predict, and their current limitations.
10 min read · 2026-06-15 Supplements · Dosing guideWhat 30+ RCTs describe about berberine's effects on blood glucose, lipids, and metabolic health — the 500 mg three-times-daily research dose, bioavailability limits, and safety considerations.
12 min read · 2026-06-25 Supplements · Dosing guideWhat 50+ studies describe about vitamin D3 dosing — deficiency thresholds, 2,000–4,000 IU maintenance doses, the role of K2 and magnesium, and why toxicity risk starts above 10,000 IU/day.
11 min read · 2026-06-26 Supplements · Stack guideBerberine, vitamin D3, omega-3, and magnesium at research doses. What the evidence describes about their individual mechanisms and combined use for metabolic health and biological age.
13 min read · 2026-06-29What the research describes about 9 longevity interventions — smoking cessation, VO2 max, physical activity, diet quality, caloric restriction, and more — ranked by strength of evidence. No advice, no marketing claims, just what trials measured with citations.